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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTD[Hydrogen Peroxide co-treated with Ammonium Sulfate] promotes the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased expression of HMOX1]PMID:15035594
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in increased activity of IFNG protein] which results in decreased susceptibility to Hydrogen Peroxide; [Hydrogen Peroxide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; [IL13 protein co-treated with IFNG protein] results in increased abundance of Hydrogen Peroxide; Hydrogen Peroxide inhibits the reaction [IFNG protein affects the localization of STAT1 protein]; Hydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]PMID:15748169 PMID:22440610 PMID:24518246 PMID:29594315
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD[IL1B protein co-treated with IFNG protein] results in increased abundance of Hydrogen Peroxide; Hydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Hydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Hydrogen Peroxide]PMID:12847270 PMID:19071154
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