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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5decreases expressionISOHspa5 (Mus musculus)6480464CTDtriptolide results in decreased expression of HSPA5 proteinPMID:26990902
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDtriptolide results in increased expression of HSPA5 mRNA; triptolide results in increased expression of HSPA5 proteinPMID:27022166 PMID:36520315
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTDSTING1 protein affects the reaction [triptolide results in increased expression of HSPA5 protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of HSPA5 mRNA]; TRAJ18 protein affects the reaction [triptolide results in increased expression of HSPA5 protein]PMID:36520315
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