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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionEXP 6480464CTDThapsigargin results in increased expression of HSPA5; Thapsigargin results in increased expression of HSPA5 mRNA; Thapsigargin results in increased expression of HSPA5 proteinPMID:16236328 PMID:16338971 PMID:17416481 PMID:17915553 PMID:18477628 PMID:21198628 PMID:22425709 PMID:23123503 PMID:28315715 PMID:28844859 PMID:32574669 PMID:35033536 PMID:35544339
Hspa5multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; GW 506033X inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]PMID:17915553 PMID:28844859 PMID:32574669
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDThapsigargin results in increased expression of HSPA5 mRNA; Thapsigargin results in increased expression of HSPA5 proteinPMID:14610226 PMID:15019097 PMID:17475668 PMID:17915553 PMID:18799549 PMID:20477944 PMID:20493918 PMID:20589738 PMID:22509299 PMID:25324550 PMID:28223344 PMID:35341795
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDThapsigargin results in increased expression of HSPA5 mRNA; Thapsigargin results in increased expression of HSPA5 proteinPMID:12147617 PMID:12198651 PMID:16298333 PMID:17283163 PMID:17332266 PMID:17353921 PMID:17416481 PMID:17915553 PMID:19135031 PMID:19139269 PMID:19428936 PMID:20626587 PMID:21320468 PMID:21692457 PMID:21694771 PMID:22378314 PMID:22800509 PMID:23885834 PMID:25295624 PMID:25324550 PMID:26264395 PMID:27358234 PMID:27578021 PMID:27587023 PMID:29126784 PMID:29453283 PMID:32357311 PMID:32535746 PMID:35033536
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTD[Thapsigargin co-treated with HRAS protein] results in increased expression of HSPA5 protein; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [arsenic trioxide results in increased expression of HSPA5 protein]; Vaticanol B inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]PMID:17475668 PMID:20493918 PMID:22509299 PMID:24898257 PMID:27638049
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; [HSPA5 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin; ATF6 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]PMID:12198651 PMID:16298333 PMID:19428936 PMID:25341683 PMID:26085089 PMID:26264395 PMID:27358234
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