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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDhydroquinone results in increased expression of HSPA5 proteinPMID:24053669 PMID:36646296 PMID:37148176
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of HSPA5 protein]PMID:36646296 PMID:37148176
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