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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2835
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:2340
Term: docebenone
Definition: A member of the class of benzoquinones that is p-benzoquinone in which the hydrogens are substituted by three methyl groups and a 12-hydroxydodeca-5,10-diyn-1-yl group.
Chemical ID: MESH:C036837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b2increases activityISOHSD11B2 (Homo sapiens)6480464CTD2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 proteinPMID:18032417
Hsd11b2multiple interactionsISOHSD11B2 (Homo sapiens)6480464CTD[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]PMID:18032417
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