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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2834
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b1increases expressionISOHsd11b1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of HSD11B1 mRNAPMID:16847310 PMID:27523796
Hsd11b1multiple interactionsISOHsd11b1 (Mus musculus)6480464CTD2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]; [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone co-treated with Lipopolysaccharides] results in decreased activity of HSD11B1 protein; Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]; zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]]PMID:27523796
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