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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:70658
Term: 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone
Definition: A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' and 4', a methoxy group at position 6' and methyl groups at positions 3' and 5'. Isolated from the buds of Cleistocalyx operculatus, it has been shown to exhibit inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2.
Chemical ID: MESH:C501649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107176480464CTD2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone results in increased expression of HMOX1 mRNA, 2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone results in increased expression of HMOX1 protein

PMID:31029725
multiple interactionsISORGD:107176480464CTDAcetylcysteine inhibits the reaction [2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone results in increased expression of HMOX1 mRNA], NFE2L2 protein affects the reaction [2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone results in increased expression of HMOX1 protein], SB 203580 inhibits the reaction [2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone results in increased expression of HMOX1 mRNA]

PMID:31029725
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.