GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | increases expression | EXP | | 6480464 | CTD | Methamphetamine results in increased expression of HMOX1 mRNA; Methamphetamine results in increased expression of HMOX1 protein | PMID:19564919 PMID:19576919 PMID:23022510 PMID:28619521 | Hmox1 | multiple interactions | EXP | | 6480464 | CTD | [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Methamphetamine; [Methamphetamine co-treated with SCH 23390] results in increased expression of HMOX1 mRNA; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in decreased susceptibility to Methamphetamine; Methamphetamine promotes the reaction [Ascorbic Acid results in increased expression of HMOX1 mRNA]; Methamphetamine promotes the reaction [Ascorbic Acid results in increased expression of HMOX1 protein]; Methamphetamine promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; Methamphetamine results in increased expression of and results in increased activity of HMOX1 protein; SB 203580 inhibits the reaction [Methamphetamine results in increased expression of HMOX1 protein]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HMOX1 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Methamphetamine results in increased activity of HMOX1 protein] | PMID:19564919 PMID:19576919 PMID:23022510 | Hmox1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Methamphetamine results in increased expression of HMOX1 protein | PMID:23933405 PMID:37567421 | Hmox1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | sulforaphane promotes the reaction [Methamphetamine results in increased expression of HMOX1 protein] | PMID:37567421 | | ||||||||||||||||||||||
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