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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:5674
Term: herbimycin
Definition: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.
Chemical ID: MESH:C020754
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107176480464CTDherbimycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]

PMID:16171798
multiple interactionsISORGD:7309016480464CTDherbimycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA], herbimycin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]

PMID:9722676
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.