GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of HMOX1 mRNA; Arsenic Trioxide results in decreased expression of HMOX1 protein | PMID:24327821 PMID:32920515 | Hmox1 | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of HMOX1 mRNA; Arsenic Trioxide results in increased expression of HMOX1 protein | PMID:27592447 PMID:27713174 PMID:28978146 PMID:29223816 | Hmox1 | multiple interactions | EXP | | 6480464 | CTD | crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; oxymatrine promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 mRNA] | PMID:24327821 PMID:27713174 PMID:28978146 PMID:32920515 | Hmox1 | decreases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of HMOX1 protein | PMID:15894607 PMID:22155346 PMID:27561292 PMID:29260515 | Hmox1 | decreases response to substance | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | HMOX1 protein results in decreased susceptibility to Arsenic Trioxide | PMID:21327864 PMID:23426167 PMID:24934751 PMID:26283888 | Hmox1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of HMOX1 mRNA; Arsenic Trioxide results in increased expression of HMOX1 protein | PMID:18336854 PMID:22488045 PMID:25815309 PMID:26187899 PMID:29049341 PMID:31473893 PMID:35872050 | Hmox1 | increases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of HMOX1; Arsenic Trioxide results in increased expression of HMOX1 mRNA; Arsenic Trioxide results in increased expression of HMOX1 protein | PMID:15725085 PMID:16487037 PMID:17258074 PMID:17547211 PMID:18636201 PMID:19128835 PMID:19350554 PMID:19408305 PMID:19417148 PMID:20471514 PMID:20950636 PMID:21315065 PMID:21327864 PMID:21945491 PMID:22155346 PMID:23426167 PMID:23649692 PMID:24392034 PMID:24801890 PMID:24934751 PMID:25003661 PMID:25246272 PMID:25258189 PMID:25873331 PMID:26110921 PMID:26260164 PMID:26283888 PMID:26705709 PMID:26708503 PMID:27829220 PMID:29633893 PMID:29662624 PMID:30317545 PMID:35276128 PMID:35872050 | Hmox1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; [Arsenic Trioxide co-treated with Grape Seed Proanthocyanidins] results in increased expression of HMOX1 mRNA; [Arsenic Trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 protein; [Arsenic Trioxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of HMOX1 protein; [Tetrachlorodibenzodioxin co-treated with Arsenic Trioxide] affects the expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [[Arsenic Trioxide results in increased abundance of Peroxides] which results in increased expression of HMOX1 protein]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; CAT protein inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; HMOX1 mRNA affects the reaction [Arsenic Trioxide results in increased expression of VEGFA mRNA]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein] | PMID:18336854 PMID:22488045 PMID:25815309 PMID:25966753 PMID:26187899 PMID:29049341 PMID:35872050 | Hmox1 | multiple interactions | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sulindac promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; 6-Aminonicotinamide inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of HMOX1 mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of HMOX1 mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to Arsenic Trioxide; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; allicin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Deoxyglucose inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Ethionamide inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein modified form]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 protein]; JUN protein promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; MIR155 mRNA inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Sulindac promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; RARA gene mutant form inhibits the reaction [Tretinoin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; SB 203580 inhibits the reaction [Sulindac promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; Sulindac promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Tetrachlorodibenzodioxin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Tretinoin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein] | PMID:18636201 PMID:19350554 PMID:21315065 PMID:21327864 PMID:23649692 PMID:24934751 PMID:25003661 PMID:25246272 PMID:25913414 PMID:26283888 PMID:26708503 PMID:27561292 PMID:27829220 PMID:29260515 PMID:30317545 PMID:33434570 PMID:35872050 | | ||||||||||||||||||||||
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