Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2806
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Hmox1
Name:	heme oxygenase 1

Acc ID:	CHEBI:40968
Term:	astaxanthin
Definition:	A carotenone that consists of beta,beta-carotene-4,4'-dione bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'S diastereomer). A carotenoid pigment found mainly in animals (crustaceans, echinoderms) but also occurring in plants. It can occur free (as a red pigment), as an ester, or as a blue, brown or green chromoprotein.
Chemical ID:	MESH:C005948

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Hmox1	decreases expression	EXP		6480464	CTD	astaxanthine results in decreased expression of HMOX1 mRNA	PMID:23272707
Hmox1	increases expression	EXP		6480464	CTD	astaxanthine results in increased expression of HMOX1 protein	PMID:20038455
Hmox1	multiple interactions	EXP		6480464	CTD	[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]	PMID:20038455 PMID:23272707
Hmox1	increases expression	ISO	HMOX1 (Homo sapiens)	6480464	CTD	astaxanthine results in increased expression of HMOX1 mRNA	PMID:24157545
Hmox1	multiple interactions	ISO	Hmox1 (Mus musculus)	6480464	CTD	astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]	PMID:33008094
Hmox1	multiple interactions	ISO	HMOX1 (Homo sapiens)	6480464	CTD	[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]	PMID:24157545 PMID:33212048

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