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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:40279
Term: allopurinol
Definition: A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
Chemical ID: MESH:D000493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDAllopurinol results in increased expression of HMOX1 mRNAPMID:25091725
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDAllopurinol inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Allopurinol inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]PMID:20888885 PMID:22659318
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