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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:3429
Term: Carnosol
Definition: A diterpenoid that has formula C20H26O4.
Chemical ID: MESH:C068623
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107176480464CTDcarnosol results in increased expression of HMOX1 mRNA, carnosol results in increased expression of HMOX1 protein

PMID:23942037
increases expressionISORGD:7309016480464CTDcarnosol results in increased expression of HMOX1 protein

PMID:20116392
multiple interactionsISORGD:107176480464CTDAcetylcysteine inhibits the reaction [carnosol results in increased expression of HMOX1 protein], HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]

PMID:23942037
multiple interactionsISORGD:7309016480464CTD[HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein, [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein, HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]], HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein], NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]

PMID:20116392
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.