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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCopper deficiency results in decreased expression of HMOX1 protein

PMID:21784888
increases expressionEXP 6480464CTDCopper deficiency results in increased expression of HMOX1 mRNA, Copper deficiency results in increased expression of HMOX1 protein

PMID:15173392
multiple interactionsEXP 6480464CTD[ATP7B protein affects the susceptibility to Copper] which affects the expression of HMOX1 mRNA, [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of HMOX1 mRNA, [Copper co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein, Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein]

PMID:20302851, PMID:23112546
increases expressionISORGD:107176480464CTDCopper analog results in increased expression of HMOX1 protein, Copper results in increased expression of HMOX1 mRNA, Copper results in increased expression of HMOX1 protein

PMID:15297030, PMID:16093525, PMID:18078826, PMID:23882024
increases expressionISORGD:7309016480464CTDCopper results in increased expression of HMOX1 mRNA, Copper results in increased expression of HMOX1 protein

PMID:17244614, PMID:19747488, PMID:19888908, PMID:24892424
multiple interactionsISORGD:107176480464CTD[Benzo(a)pyrene co-treated with Copper] results in increased expression of HMOX1 mRNA, [beta-Naphthoflavone co-treated with Copper] results in increased expression of HMOX1 mRNA, [Methylcholanthrene co-treated with Copper] results in increased expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with Copper] results in increased expression of HMOX1 mRNA, Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein], pyrazolanthrone inhibits the reaction [Copper results in increased expression of HMOX1 mRNA], pyrrolidine dithiocarbamic acid promotes the reaction [Copper results in increased expression of HMOX1 mRNA], SB 203580 inhibits the reaction [Copper results in increased expression of HMOX mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of HMOX1 mRNA], Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]], U 0126 inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]

PMID:15297030, PMID:18078826, PMID:19039664
multiple interactionsISORGD:7309016480464CTD[Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 mRNA, [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 protein, [Disulfiram binds to Copper] which results in decreased expression of HMOX1 mRNA, [NSC 689534 binds to Copper] which results in increased expression of HMOX1 mRNA, [NSC 689534 binds to Copper] which results in increased expression of HMOX1 protein, [Organoselenium Compounds binds to Copper] which results in increased expression of HMOX1 mRNA, ATP7B gene mutant form inhibits the reaction [Copper results in increased expression of HMOX1 mRNA], Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein], Copper promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA], N-(3, 5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of HMOX1 mRNA], RELA mRNA affects the reaction [Copper results in increased expression of HMOX1 mRNA]

PMID:19323979, PMID:19747488, PMID:20888885, PMID:20971185, PMID:24690739, PMID:24892424, PMID:25167922, PMID:25542178
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.