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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA, Tetrachlorodibenzodioxin results in increased expression of HMOX1 protein

PMID:11521753, PMID:16960034
multiple interactionsEXP 6480464CTD[arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA

PMID:22159698
affects expressionISORGD:107176480464CTDTetrachlorodibenzodioxin affects the expression of HMOX1 mRNA

PMID:18343893, PMID:18691609, PMID:21570461, PMID:28922406
decreases expressionISORGD:107176480464CTDTetrachlorodibenzodioxin results in decreased expression of HMOX1 mRNA, Tetrachlorodibenzodioxin results in decreased expression of HMOX1 protein

PMID:18372398, PMID:22579925
increases expressionISORGD:107176480464CTDTetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA

PMID:16960034, PMID:18078826, PMID:18163543, PMID:21846477, PMID:22535251, PMID:22579925, PMID:23231920, PMID:23423713, PMID:28213091
increases expressionISORGD:7309016480464CTDTetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA

PMID:20106945, PMID:21632981, PMID:23152189, PMID:26238291
multiple interactionsISORGD:107176480464CTD[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA, [chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA, [sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with cobaltous chloride] affects the expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with Copper] results in increased expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with Lead] results in increased expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with Mercury] results in increased expression of HMOX1 mRNA, Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], Acetylcysteine inhibits the reaction [[chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA], Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], Buthionine Sulfoximine promotes the reaction [[chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], Buthionine Sulfoximine promotes the reaction [[sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HMOX1 protein], Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA], NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HMOX1 gene], Tetrachlorodibenzodioxin promotes the reaction [Mercury results in increased expression of HMOX1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA]

PMID:15297030, PMID:16274885, PMID:17606337, PMID:17942748, PMID:18691609, PMID:18835339, PMID:21846477, PMID:22579925, PMID:23231920, PMID:23423713, PMID:28213091
multiple interactionsISORGD:7309016480464CTD[Mercuric Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA, [sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA, [tin mesoporphyrin co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA, [tin mesoporphyrin results in decreased activity of HMOX1 protein] promotes the reaction [Methylmercury Compounds results in decreased susceptibility to Tetrachlorodibenzodioxin], AHR mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [sulforafan results in increased expression of HMOX1 mRNA]], HMOX1 mRNA affects the reaction [Mercuric Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]], HMOX1 mutant form inhibits the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]], HMOX1 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]], Tetrachlorodibenzodioxin promotes the reaction [sulforafan results in increased expression of HMOX1 mRNA]

PMID:20188822, PMID:20837117, PMID:22120038, PMID:23541843, PMID:23583297
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.