Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]

PMID:12763371, PMID:15118350, PMID:15582353, PMID:15965080, PMID:16647178, PMID:17002867, PMID:24437944
decreases expressionISORGD:7309016480464CTDDactinomycin results in decreased expression of HMOX1 protein

PMID:27867098
multiple interactionsISORGD:107176480464CTDDactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 protein]

PMID:15876423, PMID:20060010, PMID:25239868, PMID:30076913
multiple interactionsISORGD:7309016480464CTDDactinomycin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [Lipid Peroxides results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Resveratrol results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA], Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein], Dactinomycin results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA], HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein], NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]]

PMID:11880364, PMID:15588712, PMID:18332044, PMID:18357586, PMID:19781563, PMID:20833156, PMID:21840424, PMID:26283888, PMID:26385185, PMID:26968795, PMID:27867098, PMID:8764571, PMID:9747510, PMID:9808084
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.