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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:24814
Term: indole-3-methanol
Definition: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Chemical ID: MESH:C016517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDindole-3-carbinol inhibits the reaction [letrozole results in decreased expression of HMOX1 protein], indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]], Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]]

PMID:28619389
multiple interactionsISORGD:107176480464CTDindole-3-carbinol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]

PMID:29775573
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.