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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDCadmium affects the expression of HMOX1 mRNA

PMID:16948784
increases expressionEXP 6480464CTDCadmium results in increased expression of HMOX1, Cadmium results in increased expression of HMOX1 mRNA, Cadmium results in increased expression of HMOX1 protein

PMID:12890491, PMID:12974610, PMID:22008531, PMID:27658547, PMID:2912370, PMID:8760880
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein], GSK3B protein affects the reaction [Cadmium results in increased expression of HMOX1 protein], Lithium Chloride promotes the reaction [Cadmium results in increased expression of HMOX1 protein], Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA], rottlerin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein], SB 216763 promotes the reaction [Cadmium results in increased expression of HMOX1 protein]

PMID:16948784, PMID:27658547
increases activityISORGD:7309016480464CTDCadmium results in increased activity of HMOX1 protein

PMID:21172416
increases expressionISORGD:107176480464CTDCadmium results in increased expression of HMOX1 mRNA, Cadmium results in increased expression of HMOX1 protein

PMID:10473555, PMID:10733587, PMID:14658758, PMID:15010501, PMID:15337587, PMID:16183037, PMID:16487038, PMID:16517059, PMID:24067728, PMID:29111403
increases expressionISORGD:7309016480464CTDCadmium results in increased expression of HMOX1 mRNA, Cadmium results in increased expression of HMOX1 protein

PMID:10349844, PMID:12716893, PMID:12783778, PMID:14647439, PMID:15242350, PMID:16020198, PMID:16816389, PMID:16959797, PMID:17156779, PMID:17204476, PMID:17244614, PMID:17547211, PMID:21120746, PMID:21172416, PMID:23794209, PMID:24284285, PMID:27005776, PMID:8077238
multiple interactionsISORGD:107176480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein, Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein], Ascorbic Acid inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA], Cadmium inhibits the reaction [BACH1 protein results in decreased expression of HMOX1 mRNA], Cadmium promotes the reaction [HMOX1 protein binds to CAV1 protein], Cadmium promotes the reaction [HMOX1 protein binds to CAV2 protein], Cadmium results in increased expression of and results in increased activity of HMOX1 protein, CTH protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein], NFE2L2 gene mutant form inhibits the reaction [Cadmium results in increased expression of HMOX1 protein], NFE2L2 protein affects the reaction [Cadmium results in increased expression of HMOX1 mRNA], O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA]

PMID:10473555, PMID:14504288, PMID:14658758, PMID:15010501, PMID:16183037, PMID:16517059, PMID:18512965, PMID:29111403, PMID:31166132
multiple interactionsISORGD:7309016480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of HMOX1 protein], [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] affects the expression of HMOX1 mRNA, [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of HMOX1 mRNA, [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA, [Water Pollutants, Chemical co-treated with Cadmium] results in increased expression of HMOX1 mRNA, Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein], Cadmium promotes the reaction [HSF1 protein binds to HMOX1 promoter], diacetyldichlorofluorescein inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA], diacetyldichlorofluorescein inhibits the reaction [Cadmium results in increased expression of HMOX1 protein], IFNG protein inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA], SB 203580 inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]

PMID:10349844, PMID:14647439, PMID:16959797, PMID:17244614, PMID:21481475, PMID:26472158, PMID:29741670
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.