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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDApigenin results in increased expression of HMOX1 mRNA; Apigenin results in increased expression of HMOX1 proteinPMID:22864849
Hmox1multiple interactionsEXP 6480464CTD[Apigenin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-ButylhydroperoxidePMID:22864849
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTDApigenin results in decreased expression of HMOX1 proteinPMID:16109301
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTDApigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]PMID:16109301
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