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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDGlucose affects the expression of HMOX1 mRNA

PMID:22643931
decreases expressionEXP 6480464CTDGlucose results in decreased expression of HMOX1 mRNA, Glucose results in decreased expression of HMOX1 protein

PMID:23770986
increases expressionEXP 6480464CTDGlucose results in increased expression of HMOX1

PMID:16464909
multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[diallyl trisulfide co-treated with Glucose] results in increased expression of HMOX1 protein], [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Glucose, [diallyl trisulfide co-treated with Glucose] results in increased expression of HMOX1 protein, [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA, Acetylcysteine affects the reaction [Glucose affects the expression of HMOX1 mRNA], Antioxidants inhibits the reaction [Glucose results in increased expression of HMOX1], cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein], cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein], Glucose results in decreased activity of and results in increased expression of HMOX1 protein, GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA]], HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]], HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]], HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]], HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]], HMOX1 protein promotes the reaction [diallyl trisulfide inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]], manganese(III)-tetrakis(4-benzoic acid)porphyrin affects the reaction [Glucose affects the expression of HMOX1 mRNA], MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA], Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein], Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein], Quercetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA], Quercetin inhibits the reaction [Glucose results in decreased expression of HMOX1 protein], zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]], zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]], zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]], zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]

PMID:16464909, PMID:22111038, PMID:22643931, PMID:23453443, PMID:23770986, PMID:24810525, PMID:25896937, PMID:29719095
decreases activityISORGD:7309016480464CTDGlucose results in decreased activity of HMOX1 promoter

PMID:14766238
decreases expressionISORGD:7309016480464CTDGlucose results in decreased expression of HMOX1 protein

PMID:21333731
increases expressionISORGD:107176480464CTDGlucose results in increased expression of HMOX1 mRNA

PMID:19489000
increases expressionISORGD:7309016480464CTDGlucose results in increased expression of HMOX1 protein

PMID:21333731, PMID:23954465
multiple interactionsISORGD:107176480464CTD[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 mRNA, Antioxidants inhibits the reaction [Glucose results in increased expression of HMOX1 mRNA], Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA], Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein], MIR144 mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 mRNA], NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]], zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]

PMID:17928392, PMID:19489000, PMID:29457851
multiple interactionsISORGD:7309016480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]], [Oxygen co-treated with Glucose] promotes the reaction [Vehicle Emissions promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein]], [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein, Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein], Glucose promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA], Glucose promotes the reaction [tin mesoporphyrin results in increased expression of HMOX1 mRNA], Particulate Matter promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein], Rosiglitazone inhibits the reaction [Glucose results in decreased expression of HMOX1 protein], Vehicle Emissions promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein]

PMID:19924377, PMID:21333731, PMID:23954465, PMID:28400208
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.