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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:17627
Term: ferroheme b
Definition: Heme b in which the iron has oxidation state +2.
Chemical ID: MESH:D006418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases abundanceEXP 6480464CTDHMOX1 protein results in decreased abundance of Heme

PMID:16959961
increases degradationEXP 6480464CTDHMOX1 protein results in increased degradation of Heme

PMID:20638379
multiple interactionsEXP 6480464CTD[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme, Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]

PMID:16959961, PMID:17292349
decreases abundanceISORGD:7309016480464CTDHMOX1 protein results in decreased abundance of Heme

PMID:18178725
decreases expressionISORGD:7309016480464CTDHeme results in decreased expression of HMOX1 mRNA

PMID:9224953
increases degradationISORGD:7309016480464CTDHMOX1 protein results in increased degradation of Heme

PMID:19136476
increases expressionISORGD:107176480464CTDHeme metabolite results in increased expression of HMOX1 mRNA, Heme results in increased expression of HMOX1 mRNA

PMID:19191707, PMID:7538129, PMID:8630002
increases expressionISORGD:7309016480464CTDHeme results in increased expression of HMOX1 mRNA, Heme results in increased expression of HMOX1 protein

PMID:10874044, PMID:12783778, PMID:15242350, PMID:17156779, PMID:19952508
increases metabolic processingISORGD:107176480464CTDHMOX1 protein results in increased metabolism of Heme

PMID:22859313
multiple interactionsISORGD:107176480464CTD[Heme binds to HPX protein] which results in increased expression of HMOX1 protein, Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein], HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA], Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]

PMID:19039664, PMID:7538129
multiple interactionsISORGD:7309016480464CTD[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron, NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA], SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]

PMID:10874044, PMID:17156779, PMID:19136476
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.