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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects expressionEXP 6480464CTDEstradiol affects the expression of HMOX1 mRNA; Estradiol affects the expression of HMOX1 proteinPMID:22389237
Hmox1multiple interactionsEXP 6480464CTD[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]; [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of HMOX1 mRNA; Estradiol affects the reaction [Paraquat affects the expression of HMOX1 protein]PMID:22389237 PMID:31715309 PMID:32741896
Hmox1affects expressionISOHmox1 (Mus musculus)6480464CTDEstradiol affects the expression of HMOX1 mRNAPMID:16684588
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDEstradiol results in increased expression of HMOX1 mRNAPMID:19484750
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDEstradiol results in increased expression of HMOX1 mRNAPMID:16298037 PMID:20106945
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of HMOX1 mRNAPMID:18691609
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of HMOX1 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of HMOX1 mRNA; Estradiol inhibits the reaction [sulforaphane results in increased expression of HMOX1 mRNA]PMID:17404688 PMID:23583297 PMID:30165855
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