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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDEthanol results in decreased activity of HMOX1 protein

PMID:20080166
decreases expressionEXP 6480464CTDEthanol results in decreased expression of HMOX1 mRNA, Ethanol results in decreased expression of HMOX1 protein

PMID:25111957, PMID:26460608, PMID:30372842
increases expressionEXP 6480464CTDEthanol results in increased expression of HMOX1 mRNA

PMID:26460608
multiple interactionsEXP 6480464CTD[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA, [Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA, Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein], Ethanol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 mRNA], Ethanol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein], Ethanol promotes the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA], Ethanol promotes the reaction [ADIPOQ protein results in increased expression of HMOX1 protein], HMOX1 protein affects the reaction [Quercetin results in decreased susceptibility to Ethanol], IL10 protein promotes the reaction [Ethanol promotes the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA]], Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA], Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA], Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein], tricarbonyldichlororuthenium (II) dimer affects the reaction [Ethanol results in decreased expression of HMOX1 protein], tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ethanol results in increased expression of HMOX1 mRNA]

PMID:20052772, PMID:20080166, PMID:22056766, PMID:25111957, PMID:26460608, PMID:26747958, PMID:30372842
decreases expressionISORGD:107176480464CTDEthanol results in decreased expression of HMOX1 mRNA, Ethanol results in decreased expression of HMOX1 protein

PMID:22552773, PMID:24144995, PMID:27983966, PMID:28419832
decreases expressionISORGD:7309016480464CTDEthanol results in decreased expression of HMOX1 mRNA, Ethanol results in decreased expression of HMOX1 protein

PMID:22484158
increases activityISORGD:7309016480464CTDEthanol results in increased activity of HMOX1 protein

PMID:17433488
increases expressionISORGD:107176480464CTDEthanol results in increased expression of HMOX1 mRNA, Ethanol results in increased expression of HMOX1 protein

PMID:20861358, PMID:25449124
increases expressionISORGD:7309016480464CTDEthanol results in increased expression of HMOX1 mRNA, Ethanol results in increased expression of HMOX1 protein

PMID:15602829, PMID:17295091
multiple interactionsISORGD:107176480464CTDdihydromyricetin inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein], Drugs, Chinese Herbal inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA], Ethanol promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein], Ethanol promotes the reaction [ethylene dichloride results in increased expression of HMOX1 mRNA], Ethanol promotes the reaction [ethylene dichloride results in increased expression of HMOX1 protein], Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]

PMID:20861358, PMID:27983966, PMID:28419832, PMID:30664321
multiple interactionsISORGD:7309016480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]], 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]], [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione], [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde], [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol, [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin, [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Iron, lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA], lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein], Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein], SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]], SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]], zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]], zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]], zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol]

PMID:15602829, PMID:17433488, PMID:22484158
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.