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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1multiple interactionsEXP 6480464CTDBerberine inhibits the reaction [Bortezomib results in increased expression of HMOX1 mRNA]PMID:35121005
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDBerberine results in increased expression of HMOX1 mRNA; Berberine results in increased expression of HMOX1 proteinPMID:37511356
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDBerberine results in increased expression of HMOX1 proteinPMID:23954465
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTDBerberine inhibits the reaction [Particulate Matter results in decreased expression of HMOX1 protein]PMID:37839514
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDBerberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]PMID:23954465
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