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GENE - TERM ANNOTATION REPORT

RGD ID: 2793
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hfe
Name: homeostatic iron regulator
Acc ID: GO:0002486
Term: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
Definition: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.
Definition Source(s): GOC:add, PMID:14647477, PMID:15771591
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hfeinvolved_inIBAPANTHER:PTN002497567 or UniProtKB:P01889 or UniProtKB:P04439 or UniProtKB:P103211600115GO_CentralGO_REF:0000033

GO_REF:0000033
Hfeinvolved_inIEAPANTHER:PTHR16675:SF1721600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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