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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2754
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta2
Name: glutathione S-transferase alpha 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta2affects expressionEXP 6480464CTDDexamethasone affects the expression of GSTA2 mRNAPMID:15102944
Gsta2decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of GSTA2 mRNA; Dexamethasone results in decreased expression of GSTA2 proteinPMID:11502894 PMID:11939905 PMID:15870285
Gsta2increases expressionEXP 6480464CTDDexamethasone results in increased expression of GSTA2 mRNA; Dexamethasone results in increased expression of GSTA2 proteinPMID:11328961 PMID:11502894 PMID:1394205 PMID:15870285 PMID:9614203
Gsta2multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [CEBPB protein results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [NFE2L2 protein results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of GSTA2 protein]; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA]; Dexamethasone promotes the reaction [benz(a)anthracene results in increased activity of GSTA2 protein]; Dexamethasone promotes the reaction [benz(a)anthracene results in increased expression of GSTA2 mRNA]; Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA2 protein]; Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA]; Glucocorticoids inhibits the reaction [Dexamethasone results in increased expression of GSTA2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA]]PMID:15870285 PMID:17690134 PMID:7587946 PMID:9614203
Gsta2multiple interactionsISOGSTA2 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GSTA2 mRNAPMID:28628672
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