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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2753
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta1
Name: glutathione S-transferase alpha 1
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta1increases expressionEXP 6480464CTDDinitrochlorobenzene results in increased expression of GSTA1 proteinPMID:9794801
Gsta1increases metabolic processingISOGSTA1 (Homo sapiens)6480464CTDGSTA1 protein results in increased metabolism of DinitrochlorobenzenePMID:3138230
Gsta1multiple interactionsISOGSTA1 (Homo sapiens)6480464CTD[GSTA1 protein binds to GSTA1 protein] which affects the metabolism of Dinitrochlorobenzene; [GSTA1 protein binds to GSTA4 protein] which affects the metabolism of Dinitrochlorobenzene; GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]PMID:11851347 PMID:12147362 PMID:14690442
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