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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grin2b
Name: glutamate ionotropic receptor NMDA type subunit 2B
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin2bincreases expressionEXP 6480464CTDColforsin results in increased expression of GRIN2B mRNA; Colforsin results in increased expression of GRIN2B proteinPMID:20067577
Grin2bmultiple interactionsEXP 6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of GRIN2B protein]PMID:20067577
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