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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2737
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grin2a
Name: glutamate ionotropic receptor NMDA type subunit 2A
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin2adecreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of GRIN2A mRNA; sodium arsenite results in decreased expression of GRIN2A proteinPMID:19041379 PMID:22421273 PMID:29723552
Grin2amultiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein]PMID:29723552
Grin2aaffects methylationISOGRIN2A (Homo sapiens)6480464CTDsodium arsenite affects the methylation of GRIN2A genePMID:28589171
Grin2adecreases expressionISOGrin2a (Mus musculus)6480464CTDsodium arsenite results in decreased expression of GRIN2A; sodium arsenite results in decreased expression of GRIN2A mRNA; sodium arsenite results in decreased expression of GRIN2A proteinPMID:29204679 PMID:31712840 PMID:37682722
Grin2aincreases expressionISOGrin2a (Mus musculus)6480464CTDsodium arsenite results in increased expression of GRIN2A proteinPMID:32194376
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