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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gnrh1
Name: gonadotropin releasing hormone 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gnrh1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GNRH1 mRNAPMID:33387578
Gnrh1decreases secretionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased secretion of GNRH1 proteinPMID:19490993
Gnrh1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of GNRH1 mRNAPMID:23871856
Gnrh1multiple interactionsEXP 6480464CTDAHR gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GNRH1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [GNRH1 protein results in increased expression of LHB mRNA]PMID:21467749 PMID:23871856
Gnrh1multiple interactionsISOGnrh1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GNRH1 promoter]PMID:19654925
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