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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of GJA1PMID:24169556
Gja1increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of GJA1 proteinPMID:31004706 PMID:35934180
Gja1multiple interactionsEXP 6480464CTDGap 26 peptide inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of GJA1 protein]PMID:35934180
Gja1decreases expressionISOGja1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in decreased expression of GJA1 mRNA; perfluorooctane sulfonic acid results in decreased expression of GJA1 proteinPMID:23948355 PMID:27818224
Gja1multiple interactionsISOGja1 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of GJA1 mRNA; Matrix Metalloproteinase Inhibitors inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]; perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]PMID:23761298 PMID:27818224 PMID:36331819
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