GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gja1 | decreases expression | EXP | | 6480464 | CTD | perfluorooctane sulfonic acid results in decreased expression of GJA1 | PMID:24169556 | Gja1 | increases expression | EXP | | 6480464 | CTD | perfluorooctane sulfonic acid results in increased expression of GJA1 protein | PMID:31004706 PMID:35934180 | Gja1 | multiple interactions | EXP | | 6480464 | CTD | Gap 26 peptide inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of GJA1 protein] | PMID:35934180 | Gja1 | decreases expression | ISO | Gja1 (Mus musculus) | 6480464 | CTD | perfluorooctane sulfonic acid results in decreased expression of GJA1 mRNA; perfluorooctane sulfonic acid results in decreased expression of GJA1 protein | PMID:23948355 PMID:27818224 | Gja1 | multiple interactions | ISO | Gja1 (Mus musculus) | 6480464 | CTD | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of GJA1 mRNA; Matrix Metalloproteinase Inhibitors inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]; perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein] | PMID:23761298 PMID:27818224 PMID:36331819 | |
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