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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1multiple interactionsISOGja1 (Mus musculus)6480464CTD[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GJA1 mRNAPMID:19840844
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased phosphorylation of GJA1 protein; Flutamide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GJA1 protein]; GJA1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDKN1A protein]; GJA1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDKN1B protein]; GJA1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCNB1 protein]; GJA1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCND1 protein]PMID:28176351
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