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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GJA1 mRNA; bisphenol A results in decreased expression of GJA1 proteinPMID:15082077 PMID:30816183 PMID:34947998 PMID:35700937
Gja1increases expressionEXP 6480464CTDbisphenol A results in increased expression of GJA1 mRNA; bisphenol A results in increased expression of GJA1 proteinPMID:19782717 PMID:25181051 PMID:28087314 PMID:32145629
Gja1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of GJA1 genePMID:28505145
Gja1multiple interactionsEXP 6480464CTD[Estradiol co-treated with bisphenol A] results in decreased expression of GJA1 mRNA; bisphenol A results in decreased expression of and affects the localization of GJA1 protein; bisphenol A results in decreased expression of and results in decreased phosphorylation of GJA1 proteinPMID:19497385 PMID:20921394 PMID:35700937
Gja1decreases expressionISOGja1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of GJA1 mRNAPMID:27022677
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GJA1 proteinPMID:37567409
Gja1decreases methylationISOGJA1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of GJA1 genePMID:31601247
Gja1increases expressionISOGja1 (Mus musculus)6480464CTDbisphenol A results in increased expression of GJA1 mRNAPMID:35479511
Gja1increases expressionISOGJA1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of GJA1 mRNAPMID:22045264
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTD[Phenolsulfonphthalein co-treated with bisphenol A deficiency] results in increased expression of GJA1 protein; [Phenolsulfonphthalein deficiency co-treated with bisphenol A deficiency] inhibits the reaction [ESRRG protein binds to GJA1 protein binds to SNAI1 protein]; [Phenolsulfonphthalein deficiency co-treated with bisphenol A deficiency] results in decreased expression of GJA1 protein; [Phenolsulfonphthalein deficiency co-treated with bisphenol A] inhibits the reaction [ESRRG protein binds to GJA1 protein binds to SNAI1 protein]; [Phenolsulfonphthalein deficiency co-treated with bisphenol A] results in increased expression of GJA1 proteinPMID:31629898
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