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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:60479
Term: lysophosphatidylcholine
Definition: An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.
Chemical ID: MESH:D008244
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1increases ubiquitinationEXP 6480464CTDLysophosphatidylcholines results in increased ubiquitination of GJA1 proteinPMID:23973256
Gja1multiple interactionsEXP 6480464CTDLysophosphatidylcholines affects the localization of and results in increased phosphorylation of GJA1 protein; PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein]PMID:23973256
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