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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2666
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gata6
Name: GATA binding protein 6
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata6increases expressionEXP 6480464CTDTretinoin results in increased expression of GATA6 mRNAPMID:20488242
Gata6affects expressionISOGATA6 (Homo sapiens)6480464CTDTretinoin affects the expression of GATA6 mRNAPMID:31600526
Gata6increases expressionISOGATA6 (Homo sapiens)6480464CTDTretinoin results in increased expression of GATA6 mRNAPMID:17034753 PMID:17138961 PMID:21934132
Gata6increases expressionISOGata6 (Mus musculus)6480464CTDTretinoin results in increased expression of GATA6 mRNAPMID:16236135 PMID:16604517 PMID:16788091
Gata6multiple interactionsISOGATA6 (Homo sapiens)6480464CTD[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of GATA6 mRNA]; [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA6 proteinPMID:23284745 PMID:31711903
Gata6multiple interactionsISOGata6 (Mus musculus)6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of GATA6 mRNAPMID:36189433
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