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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gadd45aincreases expressionEXP 6480464CTDAcetylcysteine results in increased expression of GADD45A mRNAPMID:26332274
Gadd45amultiple interactionsEXP 6480464CTD[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45A mRNA; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]PMID:22129741 PMID:24291486
Gadd45adecreases expressionISOGadd45a (Mus musculus)6480464CTDAcetylcysteine results in decreased expression of GADD45A mRNAPMID:26867644
Gadd45amultiple interactionsISOGADD45A (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Formaldehyde results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [rhododendrol results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of GADD45A mRNA]PMID:18849615 PMID:26867644
Gadd45amultiple interactionsISOGadd45a (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [raspberry ketone results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [rhododendrol results in increased expression of GADD45A mRNA]PMID:26867644
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