GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gad1 | increases expression | EXP | | 6480464 | CTD | Clozapine results in increased expression of GAD1 mRNA | PMID:12887421 PMID:15061247 PMID:18923069 | Gad1 | decreases methylation | ISO | Gad1 (Mus musculus) | 6480464 | CTD | Clozapine results in decreased methylation of GAD1 promoter | PMID:18757738 | Gad1 | increases expression | ISO | GAD1 (Homo sapiens) | 6480464 | CTD | Clozapine results in increased expression of GAD1 mRNA | PMID:17942719 | Gad1 | multiple interactions | ISO | Gad1 (Mus musculus) | 6480464 | CTD | Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter] | PMID:17942719 PMID:18757738 | |
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