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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fth1
Name: ferritin heavy chain 1
Acc ID: CHEBI:78886
Term: 2-tert-butylhydroquinone
Definition: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Chemical ID: MESH:C018855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fth1increases expressionISOFTH1 (Homo sapiens)6480464CTD2-tert-butylhydroquinone results in increased expression of FTH1 mRNAPMID:23829535 PMID:25003661
Fth1multiple interactionsISOFTH1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; PTEN protein affects the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]PMID:23829535
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