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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2630
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fshb
Name: follicle stimulating hormone subunit beta
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fshbmultiple interactionsEXP 6480464CTDDDT inhibits the reaction [FSHB protein binds to FSHR protein]PMID:17157474
Fshbincreases expressionISOFshb (Mus musculus)6480464CTDDDT results in increased expression of FSHB mRNA; DDT results in increased expression of FSHB proteinPMID:24814263
Fshbmultiple interactionsISOFshb (Mus musculus)6480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of FSHB mRNA]PMID:24814263
Fshbmultiple interactionsISOFSHB (Homo sapiens)6480464CTDDDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]PMID:26895433
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