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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FOS mRNAPMID:18164116
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDbeta-Naphthoflavone results in increased expression of FOS mRNAPMID:32151702
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FOS protein]; beta-Naphthoflavone results in decreased expression of and results in increased ubiquitination of FOS protein; UBE2L3 protein affects the reaction [beta-Naphthoflavone results in decreased expression of FOS protein]PMID:26318284
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDbeta-Naphthoflavone promotes the reaction [FOS protein binds to NQO1 promoter]PMID:8375015
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