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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:6887
Term: methylphenidate
Definition: A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
Chemical ID: MESH:D008774
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDMethylphenidate results in decreased expression of FOS proteinPMID:15916815
Fosincreases expressionEXP 6480464CTDMethylphenidate results in increased expression of FOS mRNAPMID:19931852 PMID:21753012
Fosmultiple interactionsEXP 6480464CTD[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]PMID:19931852 PMID:21753012
Fosincreases expressionISOFos (Mus musculus)6480464CTDMethylphenidate results in increased expression of FOS proteinPMID:12699766
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDMethylphenidate results in increased expression of FOS mRNA; Methylphenidate results in increased expression of FOS proteinPMID:12112414
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDSLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]PMID:12699766
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]PMID:12112414
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