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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDClozapine results in decreased expression of FOS proteinPMID:11440804
Fosincreases expressionEXP 6480464CTDClozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS proteinPMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 PMID:12243769 PMID:12464447 PMID:17028028 PMID:18208916 PMID:18521575 PMID:19695244
Fosmultiple interactionsEXP 6480464CTDClozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]PMID:10435392 PMID:12464447
Fosincreases expressionISOFos (Mus musculus)6480464CTDClozapine results in increased expression of FOS proteinPMID:28272498
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