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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDHexachlorocyclohexane results in increased expression of FOS mRNA; Hexachlorocyclohexane results in increased expression of FOS proteinPMID:10072926 PMID:1380685 PMID:1710164 PMID:7534335
Fosmultiple interactionsEXP 6480464CTDalpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]PMID:10072926 PMID:1380685 PMID:1710164 PMID:7534335
Fosincreases expressionISOFos (Mus musculus)6480464CTDHexachlorocyclohexane results in increased expression of FOS mRNAPMID:7531829
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDW 7 inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]PMID:7531829
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