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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDoxaliplatin results in increased expression of FOS mRNAPMID:25729387
Fosmultiple interactionsEXP 6480464CTD[Oxaliplatin co-treated with Topotecan] results in increased expression of FOS mRNA; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]PMID:25729387 PMID:32319158
Fosincreases expressionISOFos (Mus musculus)6480464CTDoxaliplatin results in increased expression of FOS proteinPMID:24908156
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [oxaliplatin results in increased expression of FOS protein]; Quercetin inhibits the reaction [oxaliplatin results in increased expression of FOS protein]; resveratrol inhibits the reaction [oxaliplatin results in increased expression of FOS protein]; Rutin inhibits the reaction [oxaliplatin results in increased expression of FOS protein]PMID:24908156
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