GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fn1 | increases expression | EXP | | 6480464 | CTD | Silicon Dioxide results in increased expression of FN1 protein | PMID:32097614 | Fn1 | multiple interactions | EXP | | 6480464 | CTD | tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] | PMID:32097614 | Fn1 | affects secretion | ISO | FN1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide analog affects the secretion of FN1 protein | PMID:25895662 | Fn1 | decreases expression | ISO | FN1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide analog results in decreased expression of FN1 mRNA | PMID:25895662 | Fn1 | increases expression | ISO | Fn1 (Mus musculus) | 6480464 | CTD | Silicon Dioxide analog results in increased expression of FN1 mRNA; Silicon Dioxide results in increased expression of FN1 mRNA; Silicon Dioxide results in increased expression of FN1 protein | PMID:23640035 PMID:25388157 PMID:26345256 PMID:29113749 PMID:30658076 PMID:30698894 PMID:31284023 PMID:33482250 PMID:34843873 PMID:36309172 | Fn1 | increases expression | ISO | FN1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide results in increased expression of FN1 protein | PMID:29113749 PMID:32097614 | Fn1 | multiple interactions | ISO | Fn1 (Mus musculus) | 6480464 | CTD | [IL1B protein affects the expression of FN1 mRNA] which affects the susceptibility to Silicon Dioxide; GAS6 protein affects the reaction [Silicon Dioxide results in increased expression of FN1 protein]; IL1B protein affects the reaction [Silicon Dioxide analog results in increased expression of FN1 mRNA]; IL1B protein affects the reaction [Silicon Dioxide results in increased expression of FN1 mRNA]; MERTK protein affects the reaction [Silicon Dioxide results in increased expression of FN1 mRNA]; MERTK protein affects the reaction [Silicon Dioxide results in increased expression of FN1 protein]; MIR125A mRNA inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]; MIR200C mRNA inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]; MIR490 mRNA inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]; necrostatin-1 inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]; PINK1 protein inhibits the reaction [Silicon Dioxide results in increased expression of FN1 mRNA]; Vitamin D inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] | PMID:23640035 PMID:25388157 PMID:29113749 PMID:30658076 PMID:30698894 PMID:31284023 PMID:33482250 PMID:34843873 PMID:36309172 | Fn1 | multiple interactions | ISO | FN1 (Homo sapiens) | 6480464 | CTD | [Silicon Dioxide results in increased secretion of TGFB1 protein] which results in increased expression of FN1 protein; MIR200C mRNA inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] | PMID:29113749 PMID:32097614 | |
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