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GENE - TERM ANNOTATION REPORT

RGD ID: 2611
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgfr2
Name: fibroblast growth factor receptor 2
Acc ID: GO:0070371
Term: ERK1 and ERK2 cascade
Definition: A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development.
Definition Source(s): PMID:20811974, PMID:23125017, PMID:28903453
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgfr2acts_upstream_ofISOFgfr2 (Mus musculus)1624291RGDMGI:1099809 PMID:17202188

PMID:17202188
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