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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf1
Name: fibroblast growth factor 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf1multiple interactionsEXP 6480464CTD[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF1 mRNAPMID:22129741
Fgf1increases expressionISOFgf1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of FGF1 mRNAPMID:18691550
Fgf1multiple interactionsISOFgf1 (Mus musculus)6480464CTD[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of FGF1 gene; MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FGF1 mRNA]PMID:18691550 PMID:23968726
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