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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2604
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgb
Name: fibrinogen beta chain
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgbaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of FGB mRNAPMID:22298810
Fgbincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of FGB mRNAPMID:15644576
Fgbdecreases expressionISOFgb (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FGB mRNAPMID:18796159
Fgbincreases expressionISOFGB (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of FGB mRNAPMID:20106945 PMID:21632981
Fgbmultiple interactionsISOFgb (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of FGB mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGB mRNAPMID:16214954 PMID:17942748
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