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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2603
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fga
Name: fibrinogen alpha chain
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of FGA mRNA

PMID:17108234
multiple interactionsISORGD:7372096480464CTD[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein], [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein], [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein], [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein], [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein], [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]

PMID:12616980, PMID:12616983, PMID:12618251, PMID:14561536, PMID:15288212
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.