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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2603
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fga
Name: fibrinogen alpha chain
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of FGA mRNA

PMID:15644576
decreases expressionISORGD:105766480464CTDTetrachlorodibenzodioxin results in decreased expression of FGA mRNA

PMID:21889950
decreases expressionISORGD:7372096480464CTDTetrachlorodibenzodioxin results in decreased expression of FGA mRNA

PMID:11489354, PMID:18061397, PMID:19692669, PMID:20106945, PMID:21632981
increases expressionISORGD:7372096480464CTDTetrachlorodibenzodioxin results in increased expression of FGA protein

PMID:16083274
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.